Kolbet (Iguratimod)

Iguratimod is a novel disease modifying anti-rheumatic drug (DMARD).
In a clinical study of iguratimod administered as a monotherapy in patients with rheumatoid arthritis, the agent demonstrated superiority over placebo and non-inferiority compared to an existing DMARD (salazosulfapyridine). In addition, in a trial of iguratimod in combination with methotrexate ("MTX"), the standard of care, conducted in rheumatoid arthritis patients who did not achieve satisfactory benefit with MTX alone, patients who were administered a combination of the two agents demonstrated favorable tolerability as well as significant improvements compared to those treated with placebo (MTX-only arm) in the study's primary endpoint of ACR20 response rate at Week 24. Out of all the orally-administered anti-rheumatic drugs currently approved in Japan, iguratimod is the first agent evaluated in domestic clinical trials to demonstrate efficacy as an add-on therapy to MTX in patients who did not achieve satisfactory benefit with MTX alone.

Polmacoxib (Acelex)

Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It inhibits the enzymes carbonic anhydrase and COX-2


Biofreeze products are classified as topical analgesics, which work through a 'counter irritant' mechanism. This means that the menthol in Biofreeze creates a sensation that overrides pain signals to the brain. This process is known as 'Gate Control Theory', where nerve impulses from one stimulus block the nerves containing pain signals to the brain. Research also suggests that menthol may stimulate cold receptors in the skin that may help regulate pain as well.

Crespine & Crespine +

Crespine gel manufactured by BioPloymer Germany is a single injection treatment for osteoarthritis pains in the knee, that takes only 10-20 minutes to administer and is the only drug on the market that can last up to 12 months.

Its unique efficacy is associated with the CRM technology used to double cross-link and stabilize the hyaluronic acid chains. This ensures that the body breaks down Crespine Gel slowly, resulting in a longer-lasting effect.

Pharmaceutical/ Parapharmaceutical






Metabolic & Rare Diseases


Orthopedic & Rheumatology




BroadHealth/ Food Supplements